Contamination of a fetal specimen with maternal cells may lead to inaccurate results. In order to ensure our commitment to provide the highest quality of DNA diagnostic services, maternal cell contamination studies are performed for each prenatal molecular genetics test. Our policy requires that a maternal sample be submitted to the laboratory as part of all molecular-based prenatal testing performed. Comparison of maternal and fetal samples is performed with the use of PCR analysis of multiple short tandem repeat (STR) markers. When this analysis reveals the appropriate inheritance of only one maternal allele, an accurate assessment of the fetal molecular genetic test result can be assured.

• To ensure accurate molecular prenatal diagnostic test results.
• Required in all molecular prenatal disease testing performed by the H. A. Chapman Institute.

• PCR analysis of multiple short tandem repeat (STR) loci.

• Blood EDTA (purple top) tubes: 2 tubes of 3-5 mL, OR
• Buccal Swabs: 4; please contact the laboratory for instructions.
• A Molecular Genetics Laboratory Test Requisition must accompany the specimen. Contact the Laboratory for Human Identification at 918-502-1721 to obtain further information.

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